APIXABAN

IUPAC name

1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide

CAS No.

503612-47-3

Molecular Weight

459.5 g·mol−1

Molecular Formula

C25H25N5O4

APIXABAN

Mechanism Of Action:

It’s a highly selective and reversible direct inhibitor of free and clot-bound factor Xa, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation. FXa catalyzes the conversion of prothrombin to thrombin.
 

Indication:

  • Prophylaxis of venous thromboembolism following knee or hip replacement surgery
  • Treatment of Deep Vein Thrombosis (DVT) & Pulmonary Embolism (PE)
  • Prophylaxis of recurrent DVT and PE
  • Prophylaxis of stroke and systemic embolism in non-valvular atrial fibrillation and at least one risk factor (such as previous stroke or transient ischemic attack, symptomatic heart failure, diabetes mellitus, hypertension, or age 75 years and over)