Lenalidomide hemihydrate

IUPAC name




Molecular Weight

536.5 g·mol−1

Molecular Formula


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Mechanism Of Action:

  • Exhibits immunomodulatory properties.

Activates and increases number of T cells and NK cells

Increases number of NKT cells

Inhibits pro-inflammatory cytokines (e.g., TNF-a, and IL-6) by monocytes

  • Inhibits cell proliferation and induces apoptosis of tumor cells in vitro and inhibition of tumor growth in vivo, leading to a decrease in tumor burden.
  • Inhibits angiogenesis by reducing levels of VEGF, TNF-a, and IL-6.


  • Newly diagnosed multiple myeloma(MM) in patients who have undergone/ or not eligible for autologous stem cell transplantation, and Multiple myeloma in patients who have received at least one prior therapy
  • Myelodysplastic syndromes(MDS)
  • Mantle cell lymphoma(MCL)
  • Follicular lymphoma